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Issue 3, 2011
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Structure and synthesis of 2-aminoimidazole alkaloids from Leucetta and Clathrina sponges

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Abstract

Covering: 1987 to 2010

Marine sponges belonging to the Calcarea family have been studied for some time and have yielded a wide variety of structurally unique secondary metabolites. In particular, these sponges have produced a large number of bioactive alkaloids containing an imidazole heterocycle, typically substituted with two benzylic fragments at various locations around the azole nucleus and at various oxidation states. This review will describe the isolation, structural determination and synthetic studies towards this growing class of natural products.

Graphical abstract: Structure and synthesis of 2-aminoimidazole alkaloids from Leucetta and Clathrina sponges

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Article information


Submitted
11 Jun 2010
First published
28 Oct 2010

Nat. Prod. Rep., 2011,28, 511-528
Article type
Review Article

Structure and synthesis of 2-aminoimidazole alkaloids from Leucetta and Clathrina sponges

P. B. Koswatta and C. J. Lovely, Nat. Prod. Rep., 2011, 28, 511
DOI: 10.1039/C0NP00001A

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