Issue 11, 2010
From the journal:

Natural Product Reports

Bioprospecting for antituberculosis leads from microbial metabolites

Elizabeth Jane Ashforth,†a   Chengzhang Fu,†ac   Xiangyang Liu,†a   Huanqin Dai,a   Fuhang Song,a   Hui Guoac  and  Lixin Zhang*ab  

* Corresponding authors

a Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China
E-mail: zhanglixin@im.ac.cn
Fax: +86-10-62566511
Tel: +86-10-62566511

b South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, P. R. China

c Graduate School of Chinese Academy of Sciences, Beijing, P. R. China

Abstract

Covering: 2005 to 2010

Microbial metabolites have been an important source of tuberculosis (TB) therapeutics, but the last truly novel drug that was approved for the treatment of TB was discovered 40 years ago. In light of the growing threat of multi-drug resistance, recent advances have been made to accelerate the discovery rate of novel TB drugs including diversifying strategies for environmental strains, and high-throughput screening assays. This review will discuss the approaches used in biodiversity- and taxonomy-guided microbial natural product library construction, specific cell-based and target-based high-throughput screening assays and early-stage dereplication processes by liquid chromatography–mass spectrometry (LC–MS). New antituberculosis natural products that have been recently discovered are highlighted.

Graphical abstract: Bioprospecting for antituberculosis leads from microbial metabolites

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Article information

DOI
https://doi.org/10.1039/C0NP00008F
Article type
Review Article
Submitted
24 Jun 2010
First published
04 Oct 2010

Nat. Prod. Rep., 2010,27, 1709-1719

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Bioprospecting for antituberculosis leads from microbial metabolites

E. J. Ashforth, C. Fu, X. Liu, H. Dai, F. Song, H. Guo and L. Zhang, Nat. Prod. Rep., 2010, 27, 1709 DOI: 10.1039/C0NP00008F

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