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Issue 2, 2010
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Recent advances in thiopeptideantibiotic biosynthesis

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Covering: up to the end of October 2009

Thiopeptides, or thiazolylpeptides, are a family of highly modified peptide antibiotics first discovered several decades ago. Dozens of thiopeptides have since been identified, but, until recently, the biosynthetic genes responsible for their production remained elusive. The biosynthetic systems for a handful of thiopeptide metabolites were identified in the first portion of 2009. The surprising finding that these metabolites arise from the enzymatic tailoring of a simple, linear, ribosomally-synthesized precursor peptide led to a renewed appreciation of the architectural complexity accessible by post-translational modification. This recent progress toward understanding thiopeptide antibiotic biosynthesis benefits the discovery of novel thiopeptides by either directed screening techniques or by mining available microbial genome sequences. Furthermore, access to the biosynthetic machinery now opens an avenue to the biosynthetic engineering of thiopeptide analogs. This Highlight discusses the genetic and biochemical insights revealed by these initial reports of the biosynthetic gene clusters for thiopeptide metabolites.

Graphical abstract: Recent advances in thiopeptide antibiotic biosynthesis

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Publication details

The article was received on 26 Oct 2009 and first published on 07 Dec 2009

Article type: Highlight
DOI: 10.1039/B922434C
Nat. Prod. Rep., 2010,27, 153-164

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    Recent advances in thiopeptide antibiotic biosynthesis

    C. Li and W. L. Kelly, Nat. Prod. Rep., 2010, 27, 153
    DOI: 10.1039/B922434C

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