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Issue 5, 2010
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Chemistry and biology of siderophores

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Covering: 1950 up to the end of 2009

Siderophores are compounds produced by bacteria, fungi and graminaceous plants for scavenging iron from the environment. They are low-molecular-weight compounds (500–1500 daltons) possessing a high affinity for iron(III) (Kf > 1030), the biosynthesis of which is regulated by iron levels and the function of which is to supply iron to the cell. This article briefly describes the classification and chemical properties of siderophores, before outlining research on siderophore biosynthesis and transport. Clinically important siderophores and the therapeutic potential of siderophore design are described. Appendix 1 provides a comprehensive list of siderophore structures.

Graphical abstract: Chemistry and biology of siderophores

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Publication details

The article was received on 26 Nov 2009 and first published on 07 Apr 2010

Article type: Review Article
DOI: 10.1039/B906679A
Nat. Prod. Rep., 2010,27, 637-657

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    Chemistry and biology of siderophores

    R. C. Hider and X. Kong, Nat. Prod. Rep., 2010, 27, 637
    DOI: 10.1039/B906679A

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