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Issue 11, 2009
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Metagenomic approaches to natural products from free-living and symbiotic organisms

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Abstract

Covering: up to the end of January 2009

Bacterial cultivation has been a mainstay of natural products discovery for the past 80 years. However, the majority of bacteria are recalcitrant to culture, providing an untapped source for new natural products. Metagenomic analysis provides an alternative method to directly access the uncultivated genome for natural products research and for the discovery of novel, bioactive substances. Applications of metagenomics to diverse habitats, such as soils and the interior of animals, are described.

Graphical abstract: Metagenomic approaches to natural products from free-living and symbiotic organisms

  • This article is part of the themed collection: Genomics
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Publication details

The article was received on 14 Aug 2009 and first published on 16 Sep 2009


Article type: Review Article
DOI: 10.1039/B817078A
Nat. Prod. Rep., 2009,26, 1488-1503

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    Metagenomic approaches to natural products from free-living and symbiotic organisms

    S. F. Brady, L. Simmons, J. H. Kim and E. W. Schmidt, Nat. Prod. Rep., 2009, 26, 1488
    DOI: 10.1039/B817078A

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