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Issue 1, 2009
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Aplyronine A, a potent antitumour macrolide of marine origin, and the congeners aplyronines B–H: chemistry and biology

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Abstract

Covering: up to 2007

Aplyronines A–H are cytotoxic macrolides isolated from the sea hare Aplysia kurodai. Aplyronine A is the major constituent among the aplyronines, and this review concentrates on the results of chemical and biological research into this natural product. The isolation, determination of stereostructure and enantioselective total synthesis of the aplyronines are covered, together with discussion of their antitumour activity and structure–activity relationships, and the three-dimensional X-ray structure of the actin–aplyronine A complex.

Graphical abstract: Aplyronine A, a potent antitumour macrolide of marine origin, and the congeners aplyronines B–H: chemistry and biology

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Article information


Submitted
29 Apr 2008
First published
09 Sep 2008

Nat. Prod. Rep., 2009,26, 27-43
Article type
Review Article

Aplyronine A, a potent antitumour macrolide of marine origin, and the congeners aplyronines B–H: chemistry and biology

K. Yamada, M. Ojika, H. Kigoshi and K. Suenaga, Nat. Prod. Rep., 2009, 26, 27
DOI: 10.1039/B800263K

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