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Issue 4, 2008
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Metabolic engineering of microorganisms for isoprenoid production

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Abstract

Covering: up to the end of 2007

Isoprenoids are ubiquitous in nature and range from essential cell components to unique secondary metabolites. The two isoprenoid biosynthetic pathways have received much attention from a metabolic engineering standpoint, and significant advances have been made in increasing flux through these pathways. Engineering later steps in isoprenoid biosynthetic pathways, specifically those related to the functionalization of terpene backbones, is at an earlier stage of development, both in terms of gene discovery and heterologous expression. Here we review recent advances in the metabolic engineering of microbes for isoprenoid production as well as some novel approaches to gene discovery and expression.

Graphical abstract: Metabolic engineering of microorganisms for isoprenoid production

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Publication details

The article was received on 20 Feb 2008 and first published on 25 Apr 2008


Article type: Highlight
DOI: 10.1039/B802939C
Nat. Prod. Rep., 2008,25, 656-661

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    Metabolic engineering of microorganisms for isoprenoid production

    J. Kirby and J. D. Keasling, Nat. Prod. Rep., 2008, 25, 656
    DOI: 10.1039/B802939C

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