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Issue 1, 2008
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Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products

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Abstract

Covering: up to 2007

The combination of biological and chemical approaches for the generation of new and diverse natural products holds much promise. While mutasynthesis based approaches are still very relevant, more recent approaches have utilised genetic and metabolic engineering to generate key intermediates for chemical syntheses. This new semi-synthetic approach exploits the ability of biological systems to efficiently generate complex chiral molecules and of synthetic chemistry to elaborate these into new, or difficult to source, molecules.

Graphical abstract: Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products

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Publication details

The article was received on 17 Jul 2007 and first published on 04 Sep 2007


Article type: Highlight
DOI: 10.1039/B707678A
Nat. Prod. Rep., 2008,25, 25-34

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    Mutasynthesis, chemobiosynthesis, and back to semi-synthesis: combining synthetic chemistry and biosynthetic engineering for diversifying natural products

    J. Kennedy, Nat. Prod. Rep., 2008, 25, 25
    DOI: 10.1039/B707678A

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