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Issue 6, 2005
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An update on bioactive plant lignans

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Covering: 2000 to 2004

Lignans are a class of secondary plant metabolites produced by oxidative dimerization of two phenylpropanoid units. Although their molecular backbone consists only of two phenylpropane (C6–C3) units, lignans show an enormous structural diversity. There is a growing interest in lignans and their synthetic derivatives due to applications in cancer chemotherapy and various other pharmacological effects. This review deals with lignans possessing anticancer, antioxidant, antimicrobial, anti-inflammatory and immunosuppressive activities, and comprises the data reported in more than 100 peer-reviewed articles, so as to highlight the recently reported bioactive lignans that could be a first step towards the development of potential new therapeutic agents.

Graphical abstract: An update on bioactive plant lignans

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Publication details

The article was received on 03 Oct 2005 and first published on 02 Nov 2005

Article type: Review Article
DOI: 10.1039/B514045P
Citation: Nat. Prod. Rep., 2005,22, 696-716

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    An update on bioactive plant lignans

    M. Saleem, H. J. Kim, M. S. Ali and Y. S. Lee, Nat. Prod. Rep., 2005, 22, 696
    DOI: 10.1039/B514045P

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