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Issue 6, 2020
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Multivariate analysis applied to oxidation of cyclohexane and benzyl alcohol promoted by mononuclear iron and copper complexes

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Abstract

Although univariate methodologies facilitate the interpretation of results, they may not correspond to the ideal conditions for a catalytic process. Herein, we examine the catalytic activity of an iron(III) (1) and a copper(II) (2) complex under mild conditions in the oxidation of cyclohexane (Cy) and benzyl alcohol (BnOH) with hydrogen peroxide, following a Box–Behnken multivariate experimental design. To the best of our knowledge, this is the first report of the application of this tool to the homogeneous oxidation of these organic substrates. The multivariate approach allowed a range of optimal conditions to be identified for the variables studied. Complex 1 was able to convert higher amounts of the studied substrates into products when compared with 2. However, 2 presented higher selectivity toward the generation of cyclohexanol (CyOH) and benzaldehyde (BA) than 1, although the conversion rates were lower.

Graphical abstract: Multivariate analysis applied to oxidation of cyclohexane and benzyl alcohol promoted by mononuclear iron and copper complexes

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Supplementary files

Article information


Submitted
05 Nov 2019
Accepted
07 Jan 2020
First published
09 Jan 2020

New J. Chem., 2020,44, 2514-2526
Article type
Paper

Multivariate analysis applied to oxidation of cyclohexane and benzyl alcohol promoted by mononuclear iron and copper complexes

A. F. Vailati, R. D. Huelsmann, E. Martendal, A. J. Bortoluzzi, F. R. Xavier and R. A. Peralta, New J. Chem., 2020, 44, 2514
DOI: 10.1039/C9NJ05534G

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