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Issue 39, 2019
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Chemoselective reduction of aldehydes via a combination of NaBH4 and acetylacetone

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Abstract

A bench-stable combination of NaBH4-acetylacetone was developed for the efficient chemoselective reduction of aldehydes in the presence of ketones. This method offers a useful synthetic protocol for distinguishing carbonyl reaction sites, and its synthetic utility is reflected by its moisture tolerance and high efficiency in a variety of complex settings.

Graphical abstract: Chemoselective reduction of aldehydes via a combination of NaBH4 and acetylacetone

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Supplementary files

Article information


Submitted
21 Jun 2019
Accepted
08 Sep 2019
First published
09 Sep 2019

New J. Chem., 2019,43, 15793-15796
Article type
Paper

Chemoselective reduction of aldehydes via a combination of NaBH4 and acetylacetone

G. Sui, Q. Lv, X. Song, H. Guo, J. Dai, L. Ren, C. Lee, W. Zhou and H. Hao, New J. Chem., 2019, 43, 15793
DOI: 10.1039/C9NJ03210J

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