Ruthenium catalyzed chemo and site-selective C–H amidation of oxobenzoxazine derivatives with sulfonyl azides

Abstract

An efficient, novel and general protocol towards the synthesis of highly functionalized ortho-amido oxobenzoxazine frameworks via ruthenium catalyzed intermolecular C–H amidation using sulfonyl azides as amidation components has been successfully developed for the first time. The salient features of this strategy are high chemo and site-selectivity, a wide range of substrate scope with excellent yields and good functional group tolerance.