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Issue 11, 2019
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Four-component, three-step cascade reaction: an effective synthesis of indazole-fused triazolo[5,1-c]quinoxalines

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Abstract

An efficient four-component, three-step cascade reaction was developed for the synthesis of indazole-fused triazolo[5,1-c]quinoxalines from o-azido aldehyde, o-iodoaniline, phenylacetylene, and sodium azide. The methodology involves the sequential formation of 2H-indazole, then azide–alkyne cycloaddition, followed by C–N coupling, and finally intramolecular cross-dehydrogenative C–C coupling. Notable features of this protocol include simple starting materials, reduced synthetic steps, and good yields.

Graphical abstract: Four-component, three-step cascade reaction: an effective synthesis of indazole-fused triazolo[5,1-c]quinoxalines

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Article information


Submitted
13 Dec 2018
Accepted
04 Feb 2019
First published
07 Feb 2019

New J. Chem., 2019,43, 4333-4337
Article type
Letter

Four-component, three-step cascade reaction: an effective synthesis of indazole-fused triazolo[5,1-c]quinoxalines

K. Shiva Kumar, P. K. Naikawadi, B. Rajesham and D. Rambabu, New J. Chem., 2019, 43, 4333
DOI: 10.1039/C8NJ06299D

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