Iodine-mediated sulfenylation of 4-hydroxycoumarins with sulfonyl hydrazides under aqueous conditions†
Abstract
An efficient, metal-free approach to the synthesis of sulfenylated coumarins based on the iodine catalyzed regioselective sulfenylation of 4-hydroxycoumarins with arylsulfonyl hydrazides was developed under mild conditions in water. Various sulfenylated coumarin derivatives were obtained in good to excellent yields with good functional group tolerance.