Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 21, 2018
Previous Article Next Article

A novel photosensitizer based on a ruthenium(II) phenanthroline bis(perylenediimide) dyad: synthesis, generation of singlet oxygen and in vitro photodynamic therapy

Author affiliations

Abstract

In this study, a novel photosensitizer having two perylenediimide units and a phenanthroline ruthenium(II) coordination moiety (Ru-BP) has been developed for photodynamic therapy (PDT) of cancer cells. This new compound was prepared via reactions of two newly designed molecules, namely, 5,6,12,13-tetrakis(4-(tert-butyl)phenoxy)-2-(2,6-diisopropylphenyl)-9-(4-hydroxyphenyl)anthra[2,1,9-def:6,5,10-def′]diisoquinoline-1,3,8,10(2H,9H)-tetraone (P6) and a bis(2,2′-bipyridyl)-(4,7-dichlorophenanthroline)ruthenium(II) complex (7). The singlet oxygen production of P6 and Ru-BP was investigated by a chemical method using 1,3-diphenylisobenzofurane as a trap molecule. Additionally, photodynamic therapy efficacy of the novel Ru-BP complex and P6 was evaluated in vitro. Ru-BP significantly decreased the viability of human chronic myeloid leukemia cells under red light but not in the dark, pointing out that the complex, itself, was not cytotoxic and singlet oxygen formation was required for the initiation of cell death mechanisms. Thus, Ru-BP can be effectively used as a photosensitizer in photodynamic therapy, which makes the novel Ru-BP a promising singlet oxygen generator for further biological applications.

Graphical abstract: A novel photosensitizer based on a ruthenium(ii) phenanthroline bis(perylenediimide) dyad: synthesis, generation of singlet oxygen and in vitro photodynamic therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Jun 2018, accepted on 26 Sep 2018 and first published on 26 Sep 2018


Article type: Paper
DOI: 10.1039/C8NJ02944J
Citation: New J. Chem., 2018,42, 17538-17545

  •   Request permissions

    A novel photosensitizer based on a ruthenium(II) phenanthroline bis(perylenediimide) dyad: synthesis, generation of singlet oxygen and in vitro photodynamic therapy

    N. E. Aksakal, H. H. Kazan, E. T. Eçik and F. Yuksel, New J. Chem., 2018, 42, 17538
    DOI: 10.1039/C8NJ02944J

Search articles by author

Spotlight

Advertisements