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Issue 16, 2018
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Orientalol L–P, novel sesquiterpenes from the rhizome of Alisma orientale (Sam.) Juzep and their nephrotoxicity on HK2 cells

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Abstract

Two new sesquiterpenes (1–2) and three new nor-sesquiterpenes (3–5) were obtained from the rhizome of Alisma orientale (Sam.) Juzep, one of which (2) possessed an unprecedented cyclopentene and furanone containing natural skeleton. Their structures and relative stereochemistry were elucidated by NMR spectroscopy (1H and 13C NMR, HSQC, HMBC, NOESY) and electronic circular dichroism (ECD) and HR-ESI-MS data analyses. Two plausible biosynthetic pathways for compound 1 and 2 were discussed. The nephrotoxicities of these compounds were evaluated on normal human HK2 cells by high content screening, and neither the MeOH extract nor the compounds possessed potential nephrotoxicity in vitro.

Graphical abstract: Orientalol L–P, novel sesquiterpenes from the rhizome of Alisma orientale (Sam.) Juzep and their nephrotoxicity on HK2 cells

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Article information


Submitted
02 May 2018
Accepted
18 Jun 2018
First published
18 Jul 2018

New J. Chem., 2018,42, 13414-13420
Article type
Paper

Orientalol L–P, novel sesquiterpenes from the rhizome of Alisma orientale (Sam.) Juzep and their nephrotoxicity on HK2 cells

J. Zhang, Q. Jin, S. Li, J. Wu, Z. Wang, J. Hou, H. Qu, H. Long, W. Wu and D. Guo, New J. Chem., 2018, 42, 13414
DOI: 10.1039/C8NJ02027B

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