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Issue 15, 2018

Triple detection modes for Hg2+ sensing based on a NBD-fluorescent and colorimetric sensor and its potential in cell imaging

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Abstract

A new fluorescent sensor (DiNBD) was successfully synthesized; the sensor consisted of two 7-nitrobenzo-2-oxa-1,3-diazolyl (NBD) units that were covalently attached to 2-(4-(2-aminoethylthio)butylthio)ethanamine by a conventional two-step synthesis. It could serve as a colorimetric and fluorescent sensor for Hg2+ in aqueous acetonitrile solutions with high selectivity over other competitive metal ions. Upon Hg2+ titration, the sensor exhibited “ON–OFF” fluorescence quenching at 526 nm (λex 458 nm) and “OFF–ON” fluorescence enhancement at 560 nm (λex 530 nm), which were accompanied by a colorimetric change from yellow to red. The Hg2+ detection limit of the sensor was 0.7 ppb, which is lower than the permitted level of Hg2+ in drinking water regulated by US EPA and WHO. Additionally, the fluorescence quenching and fluorescence enhancement of the sensor in the presence of Hg2+ could provide a precise determination of Hg2+ concentration due to their self-calibration. Moreover, the DiNBD fluorescent sensor could be used to determine Hg2+ in real samples and living cells, which could widen the applications of the developed sensor.

Graphical abstract: Triple detection modes for Hg2+ sensing based on a NBD-fluorescent and colorimetric sensor and its potential in cell imaging

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Supplementary files

Article information


Submitted
20 Apr 2018
Accepted
08 Jun 2018
First published
20 Jun 2018

New J. Chem., 2018,42, 12412-12420
Article type
Paper

Triple detection modes for Hg2+ sensing based on a NBD-fluorescent and colorimetric sensor and its potential in cell imaging

S. Kraithong, R. Sangsuwan, N. Worawannotai, J. Sirirak, A. Charoenpanich, P. Thamyongkit and N. Wanichachewa, New J. Chem., 2018, 42, 12412 DOI: 10.1039/C8NJ01915K

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