Rhodamine–benzothiazole conjugate as an efficient multimodal sensor for Hg2+ ions and its application to imaging in living cells

Perumal Sakthivel; Karuppannan Sekar; Gandhi Sivaraman; Subramanian Singaravadivel

doi:10.1039/C8NJ01736K

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Rhodamine–benzothiazole conjugate as an efficient multimodal sensor for Hg²⁺ ions and its application to imaging in living cells†

Perumal Sakthivel,^a Karuppannan Sekar,

*^a Gandhi Sivaraman

*^b and Subramanian Singaravadivel^c

Author affiliations

* Corresponding authors

^a Department of Chemistry, Anna University – University College of Engineering Dindigul, Dindigul-624622, India
E-mail: karuppannansekar@gmail.com
Fax: +91-451-2554066
Tel: +91-451-2554066

^b Institute for Stem Cell Biology and Regenerative Medicine, Bangalore-560065, India
E-mail: raman474@gmail.com

^c Department of Chemistry, SSM Institute of Engineering and Technology, Dindigul-624002, India

Abstract

A rhodamine B dye bearing a benzothiazole (RBT-1) conjugate is designed and synthesized, it shows a highly selective and sensitive naked-eye color change and turn-on fluorescence response to Hg²⁺ ions. The detection limit of RBT-1 towards Hg²⁺ is found to be 0.17 nM. RBT-1 exhibits low cytotoxicity and cell membrane permeability, which makes it capable of sensing Hg²⁺ in HeLa cells and real water samples.

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Article information

DOI: https://doi.org/10.1039/C8NJ01736K
Article type: Paper
Submitted: 12 Apr 2018
Accepted: 30 May 2018
First published: 07 Jun 2018

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New J. Chem., 2018,42, 11665-11672

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Rhodamine–benzothiazole conjugate as an efficient multimodal sensor for Hg²⁺ ions and its application to imaging in living cells

P. Sakthivel, K. Sekar, G. Sivaraman and S. Singaravadivel, New J. Chem., 2018, 42, 11665 DOI: 10.1039/C8NJ01736K

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