Issue 7, 2018
From the journal:

New Journal of Chemistry

A sensitive two-photon ratiometric fluorescent probe for γ-glutamyltranspeptidase activity detection and imaging in living cells and cancer tissues†

Wei Liu, ORCID logo *a   Bo Huang,b   Zong-Xuan Tong,b   Shuanglong Wang,a   Yi-Jin Lia  and  Yu-You Daia  

* Corresponding authors

a Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang 330013, P. R. China
E-mail: wendao_wei@163.com
Fax: +86-791-83896370
Tel: +86-791-83896370

b State Key Laboratory of Chemo/BioSensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China

Abstract

We develop a novel two-photon ratiometric fluorescent probe based on the conjugation of the specific recognition moiety of the γ-glutamyl group to 6-acetyl-2-aminonaphthalene, which enables highly sensitive, selective monitoring of γ-glutamyltransferase activities in human serum and imaging in living cells and cancer tissues down to a depth of 120 μm.

Graphical abstract: A sensitive two-photon ratiometric fluorescent probe for γ-glutamyltranspeptidase activity detection and imaging in living cells and cancer tissues

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Article information

DOI
https://doi.org/10.1039/C8NJ00520F
Article type
Paper
Submitted
30 Jan 2018
Accepted
22 Feb 2018
First published
28 Feb 2018

New J. Chem., 2018,42, 5403-5407

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A sensitive two-photon ratiometric fluorescent probe for γ-glutamyltranspeptidase activity detection and imaging in living cells and cancer tissues

W. Liu, B. Huang, Z. Tong, S. Wang, Y. Li and Y. Dai, New J. Chem., 2018, 42, 5403 DOI: 10.1039/C8NJ00520F

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