A new ratiometric fluorescent probe for detecting endogenous HClO in living cells

Li-Jie Zhang; Jun-Ya Ning; Jun-Ying Miao; Jin-Ting Liu; Bao-Xiang Zhao

doi:10.1039/C7NJ03907G

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A new ratiometric fluorescent probe for detecting endogenous HClO in living cells†

Li-Jie Zhang,‡^ab Jun-Ya Ning,‡^c Jun-Ying Miao,

^c Jin-Ting Liu*^a and Bao-Xiang Zhao

*^a

Author affiliations

* Corresponding authors

^a Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China
E-mail: bxzhao@sdu.edu.cn, Jintliu@sdu.edu.cn
Tel: +86 531 88366425

^b School of Chemistry, Sun Yat-Sen University, Guangzhou 510220, P. R. China

^c Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, P. R. China

Abstract

A new benzimidazole-hemicyanine-based ratiometric fluorescent probe (ZBM-H) was developed, which showed high selectivity and sensitivity for detecting HClO. Furthermore, ZBM-H with a longer wavelength emission (653 nm), good membrane permeability and less cytotoxicity was successfully used to image the exogenous and endogenous HClO in RAW264.7 cells.

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Article information

DOI: https://doi.org/10.1039/C7NJ03907G
Article type: Paper
Submitted: 11 Oct 2017
Accepted: 11 Jan 2018
First published: 12 Jan 2018

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New J. Chem., 2018,42, 2989-2993

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A new ratiometric fluorescent probe for detecting endogenous HClO in living cells

L. Zhang, J. Ning, J. Miao, J. Liu and B. Zhao, New J. Chem., 2018, 42, 2989 DOI: 10.1039/C7NJ03907G

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New Journal of Chemistry

A new ratiometric fluorescent probe for detecting endogenous HClO in living cells†

Abstract

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A new ratiometric fluorescent probe for detecting endogenous HClO in living cells

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