Issue 1, 2018

Photoredox catalysed synthesis of amino alcohol

Abstract

A mild and efficient one-pot visible light-induced method has been developed for the synthesis of amino alcohols. Amino alcohols are important structural elements that are frequently found in pharmaceutical agents and biologically active natural products. The routine procedure in the drug discovery and development process to prepare and fully characterize amino alcohols makes them a drug candidate for biological evaluation. This protocol utilizes visible light as the greenest reagent and eosin Y as an organophotoredox catalyst to synthesise bioactive amino alcohols. Gram scale reactions demonstrated the potential synthetic applications of this protocol.

Graphical abstract: Photoredox catalysed synthesis of amino alcohol

Supplementary files

Article information

Article type
Paper
Submitted
17 Aug 2017
Accepted
26 Nov 2017
First published
29 Nov 2017

New J. Chem., 2018,42, 688-691

Photoredox catalysed synthesis of amino alcohol

V. Srivastava, P. K. Singh, S. Kanaujia and P. P. Singh, New J. Chem., 2018, 42, 688 DOI: 10.1039/C7NJ03068A

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