Issue 17, 2017

Fluorinated near-infrared fluorescent probes for specific detection of Hg2+ in an aqueous medium and mitochondria of living cells

Abstract

Mitochondria are one of the major targets for localization of mercury ions, where serious mercury-induced toxicity has been well documented. Here, we design two heptamethine cyanine dyes coupled with thymines on the N-alkyl chains, which can specifically chelate with Hg2+ by forming a T–Hg–T complex to sensitively detect Hg2+ in both aqueous solution and the mitochondria of living cells. Further studies revealed that the introduction of fluorine atoms on thymines would significantly enhance the binding ability of T–Hg–T, providing clues to develop more specific and sensitive Hg2+ sensors.

Graphical abstract: Fluorinated near-infrared fluorescent probes for specific detection of Hg2+ in an aqueous medium and mitochondria of living cells

Supplementary files

Article information

Article type
Paper
Submitted
21 Apr 2017
Accepted
10 Jul 2017
First published
11 Jul 2017

New J. Chem., 2017,41, 8899-8904

Fluorinated near-infrared fluorescent probes for specific detection of Hg2+ in an aqueous medium and mitochondria of living cells

L. Long, X. Tan, S. Luo and C. Shi, New J. Chem., 2017, 41, 8899 DOI: 10.1039/C7NJ01327B

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