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Issue 8, 2016
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A new series of bipyridine based chiral organocatalysts for enantioselective Henry reaction

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Abstract

A series of binaphthol based chiral organocatalysts were synthesized and applied as metal-free organocatalysts in the enantioselective Henry reaction. These organocatalysts enabled the Henry reaction with a lower concentration of catalysts at room temperature affording the desired S- or undesired R-enantiomers. The formation of R- and S-enantiomers of β-nitroalcohol products strongly depends on the temperature/substrate inversion of configuration for the effective catalytic enantioselective Henry reaction in high yields (up to 97%) with excellent enantioselectivities (up to 99% ee).

Graphical abstract: A new series of bipyridine based chiral organocatalysts for enantioselective Henry reaction

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Publication details

The article was received on 05 Apr 2016, accepted on 21 Jun 2016 and first published on 22 Jun 2016


Article type: Paper
DOI: 10.1039/C6NJ01045H
Citation: New J. Chem., 2016,40, 7148-7156
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    A new series of bipyridine based chiral organocatalysts for enantioselective Henry reaction

    V. Ashokkumar, K. Duraimurugan and A. Siva, New J. Chem., 2016, 40, 7148
    DOI: 10.1039/C6NJ01045H

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