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Issue 7, 2016
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RAPTA-C incorporation and controlled delivery from MIL-100(Fe) nanoparticles

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Abstract

[Fe3F(H2O)2O(btc)2nH2O (H3btc: benzene-1,3,5-tricarboxylic acid) (MIL-100(Fe)) in the form of nanoparticles with average size of 135 ± 70 nm can be used for the adsorption and controlled delivery of metallodrug [Ru(p-cymene)Cl2(pta)] (RAPTA-C) in simulated body fluid (SBF). The results show that the RAPTA-C delivery process takes place in two steps exhibiting half-life times of 1.9 and 30 h. We also found a positive effect of bovine serum albumine (BSA) in speeding up the RAPTA-C delivery rate, which agrees with the suitability of MIL-100(Fe) as a drug delivery system (DDS) for the controlled release of RAPTA-C.

Graphical abstract: RAPTA-C incorporation and controlled delivery from MIL-100(Fe) nanoparticles

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Publication details

The article was received on 06 Oct 2015, accepted on 01 Dec 2015 and first published on 02 Dec 2015


Article type: Paper
DOI: 10.1039/C5NJ02741A
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New J. Chem., 2016,40, 5690-5694

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    RAPTA-C incorporation and controlled delivery from MIL-100(Fe) nanoparticles

    S. Rojas, F. J. Carmona, C. R. Maldonado, E. Barea and J. A. R. Navarro, New J. Chem., 2016, 40, 5690
    DOI: 10.1039/C5NJ02741A

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