Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 2, 2016
Previous Article Next Article

In vitro antiproliferative activity of palladium(ii) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles

Author affiliations

Abstract

This work reports the synthesis and characterization of palladium(II) complexes Pd(L1)2 (1), Pd(L2)2 (2), Pd(L3)2 (3) and Pd(L4)2 (4), where L1H: 1-naphthaldehyde thiosemicarbazone; L2H: 4-phenyl-(1-naphthaldehyde)thiosemicarbazone; L3H: (2-hydroxy-1-naphthaldehyde)thiosemicarbazone; L4H: 4-phenyl-1-(2-hydroxy-1-naphthaldehyde)thiosemicarbazone. All four complexes show in vitro antiproliferative activity against the following human tumor cell lines: H460, DU145, MCF-7, M14, HT-29, K562, and HuTu 80. In particular Pd(L1)2 has the most potent activity for all the studied cell lines (IC50 ∼ 1 μM), with the exception of H460. Pd(L2)2 is a promising candidate as a pharmacological agent, since it presents a significant activity and is more innocuous than cisplatin against mouse fibroblast normal cells, 3T3. Pd(L4)2 is the complex which exhibits the lowest activity against the same cell line (IC50 ∼ 11 μM), being ten times lower than that of Pd(L1)2. These complexes were used to functionalize chitosan coated superparamagnetic magnetite nanoparticles with a metallic core of 11–13 nm, and the activity of these functionalized nanoparticles (NPs) against diverse human tumor cell lines was also tested. The nanoparticles functionalized with Pd(L1)2, Pd(L3)2 and Pd(L4)2 show antiproliferative activity against DU-145, while those with Pd(L2)2, Pd(L3)2 and Pd(L4)2 against HuTu80.

Graphical abstract: In vitro antiproliferative activity of palladium(ii) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles

Back to tab navigation

Supplementary files

Article information


Submitted
10 Sep 2015
Accepted
08 Dec 2015
First published
11 Dec 2015

New J. Chem., 2016,40, 1853-1860
Article type
Paper
Author version available

In vitro antiproliferative activity of palladium(II) thiosemicarbazone complexes and the corresponding functionalized chitosan coated magnetite nanoparticles

W. Hernández, Abraham. J. Vaisberg, M. Tobar, M. Álvarez, J. Manzur, Y. Echevarría and E. Spodine, New J. Chem., 2016, 40, 1853
DOI: 10.1039/C5NJ02429C

Social activity

Search articles by author

Spotlight

Advertisements