Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 5, 2015
Previous Article Next Article

One-pot and facile synthesis of anti-biofouling polymer-modified gadolinium-based nanoprobes for dual-modal imaging and long-lasting tracking

Author affiliations

Abstract

Multi-modal imaging in tissue and animals has integrated the advantages of individual molecular imaging modalities and shown great potential in both pre-clinical and clinical fields. In the present work, a high-performance nanoparticulate contrast agent based on PEGylated gadolinium hydroxycarbonate nanoparticles (PEG-GdNPs) was designed and synthesized via a facile approach. Due to the outstanding X-ray absorption coefficient/K-edge value and the presence of unpaired 4f electrons of element Gd, our well-prepared nanoprobes were successfully used as dual-modal contrast agents for in vivo synergistic magnetic resonance and X-ray computed tomography imaging. Bio-distribution of the nanoparticles was further studied via in vivo long-term tracking during the imaging process, revealing that most of the nanoprobes could accumulate in the liver and therefore act as a liver-targeted imaging agent. Moreover, toxicity including cell viability, blood biochemical assay, as well as changes in body weight and histology indicated the low systemic toxicity of our nanoprobes. Taken together, we believe that PEG-GdNPs with their excellent imaging capability and high biocompatibility may find widespread application in the field of biomedicine.

Graphical abstract: One-pot and facile synthesis of anti-biofouling polymer-modified gadolinium-based nanoprobes for dual-modal imaging and long-lasting tracking

Back to tab navigation

Supplementary files

Article information


Submitted
19 Jan 2015
Accepted
06 Mar 2015
First published
09 Mar 2015

New J. Chem., 2015,39, 4020-4025
Article type
Paper

One-pot and facile synthesis of anti-biofouling polymer-modified gadolinium-based nanoprobes for dual-modal imaging and long-lasting tracking

D. Wu, L. Song, Z. Qi and D. Qu, New J. Chem., 2015, 39, 4020
DOI: 10.1039/C5NJ00150A

Social activity

Search articles by author

Spotlight

Advertisements