Jump to main content
Jump to site search

Issue 3, 2015
Previous Article Next Article

A novel VS2 nanosheet-based biosensor for rapid fluorescence detection of cytochrome c

Author affiliations

Abstract

A novel ultrasensitive sensing system for rapid fluorescence detection of cytochrome c (cyt c) was proposed by combining aptamer-based bioassay with VS2 nanosheets. VS2 nanosheets with high fluorescence quenching ability were synthesized by the solution route. A cyt c-binding aptamer was tagged with the fluorescent dye carboxy fluorescein (FAM), acting as the probe. VS2 nanosheets can adsorb the probe and quench its fluorescence efficiently. However, the fluorescence of the probe was retained when it was incubated with cyt c and then mixed with VS2 nanosheet solution. The proposed sensing system shows high selectivity and sensitivity, giving a linear range of 0.75 nM to 50 μM, and a limit of detection of 0.50 nM.

Graphical abstract: A novel VS2 nanosheet-based biosensor for rapid fluorescence detection of cytochrome c

Back to tab navigation

Article information


Submitted
06 Nov 2014
Accepted
17 Dec 2014
First published
17 Dec 2014

New J. Chem., 2015,39, 1892-1898
Article type
Paper
Author version available

A novel VS2 nanosheet-based biosensor for rapid fluorescence detection of cytochrome c

X. Yin, J. Cai, H. Feng, Z. Wu, J. Zou and Q. Cai, New J. Chem., 2015, 39, 1892
DOI: 10.1039/C4NJ01971G

Social activity

Search articles by author

Spotlight

Advertisements