Issue 4, 2015

A closer look into the ubiquitin corona on gold nanoparticles by computational studies

Abstract

In this study, coarse-grained computational simulations of the ubiquitin corona around gold nanoparticles have been carried out, and the effect of the nanoparticle size (10, 16, 20, and 24 nm diameter) and environment (bare nanoparticle surface, and citrate-coated surface, where citrate are treated with implicit and explicit models) has been analysed. The results showed that the corona is obtained after a slow reorientation step that occurs at the nanoparticle surface in order to optimize the nanoparticle–ubiquitins interaction. The ubiquitin binding modalities depend on the nanoparticle environment, while conformational changes of ubiquitins upon binding and their aggregation propensity slightly depend on nanoparticle size.

Graphical abstract: A closer look into the ubiquitin corona on gold nanoparticles by computational studies

Supplementary files

Article information

Article type
Paper
Submitted
07 Oct 2014
Accepted
15 Dec 2014
First published
16 Dec 2014

New J. Chem., 2015,39, 2474-2482

Author version available

A closer look into the ubiquitin corona on gold nanoparticles by computational studies

F. Tavanti, A. Pedone and M. C. Menziani, New J. Chem., 2015, 39, 2474 DOI: 10.1039/C4NJ01752H

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