Jump to main content
Jump to site search

Issue 9, 2014
Previous Article Next Article

DNA-based nanocomposite as electrochemical chiral sensing platform for the enantioselective interaction with quinine and quinidine

Author affiliations

Abstract

A novel chiral sensing platform, employing a biomolecule-based nanocomposite prepared by calf thymus double stranded DNA, methylene blue and multiwall carbon nanotubes (DNA–MB–MWNTs), was utilized for the discrimination of quinine (QN) and quinidine (QD). The DNA-based nanocomposite, which could be used as an electrochemical sensing unit and chiral probe, was characterized by transmission electron microscopy (TEM), ultraviolet-visible spectroscopy (UV-Vis) and cyclic voltammetry (CV). After the proposed sensing platform interacted with QN and QD, a larger electrochemical signal was obtained from QD. The comparative experiments indicated that the proposed strategy not only simplified the fabrication processes but also enhanced the enantioselective interaction in chiral analysis. In addition, experimental factors such as acidity, interaction time and the concentration of enantiomers were investigated in regards to the effect on enantioselective interaction.

Graphical abstract: DNA-based nanocomposite as electrochemical chiral sensing platform for the enantioselective interaction with quinine and quinidine

Back to tab navigation

Supplementary files

Article information


Submitted
11 Dec 2013
Accepted
02 Jul 2014
First published
02 Jul 2014

New J. Chem., 2014,38, 4600-4606
Article type
Paper
Author version available

DNA-based nanocomposite as electrochemical chiral sensing platform for the enantioselective interaction with quinine and quinidine

Q. Zhang, Y. Huang, L. Guo, C. Chen, D. Guo, Y. Chen and Y. Fu, New J. Chem., 2014, 38, 4600
DOI: 10.1039/C3NJ01559A

Social activity

Search articles by author

Spotlight

Advertisements