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Issue 4, 2013
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One-pot synthesis of 2,4,5-trisubstituted 1,2,3-triazoles through the cascade reactions of acid chlorides, terminal acetylenes, sodium azide and aryl halides

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Abstract

An efficient one-pot reaction of acid chlorides, terminal acetylenes, sodium azide and aryl halides is developed for the regioselective synthesis of 2,4,5-trisubstituted 1,2,3-triazoles. The method is general, convenient, eco-friendly, atom-economical, and could provide excellent yields and regioselectivities.

Graphical abstract: One-pot synthesis of 2,4,5-trisubstituted 1,2,3-triazoles through the cascade reactions of acid chlorides, terminal acetylenes, sodium azide and aryl halides

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Publication details

The article was received on 10 Oct 2012, accepted on 11 Jan 2013 and first published on 14 Jan 2013


Article type: Paper
DOI: 10.1039/C3NJ40912K
New J. Chem., 2013,37, 965-968

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    One-pot synthesis of 2,4,5-trisubstituted 1,2,3-triazoles through the cascade reactions of acid chlorides, terminal acetylenes, sodium azide and aryl halides

    X. Liu, J. Li and B. Chen, New J. Chem., 2013, 37, 965
    DOI: 10.1039/C3NJ40912K

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