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Issue 11, 2013
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Synthesis of Ag-glyconanoparticles using C-glycosides, their lectin binding studies and antibacterial activity

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Abstract

Two 12-C-glycosyl dodecanoic acids, namely, 1-(α-D-mannopyranosyl)-12-dodecanoic acid and 1-(α-D-glucopyranosyl)-12-dodecanoic acid were synthesized. Their ability to act as reducing and capping agents for the synthesis of water re-dispersible silver nanoparticles is displayed. These Ag C-glycosyl nanoparticles were later utilized to investigate the carbohydrate–lectin interactions. Furthermore, the specificity of mannoside binding to the surface of the Gram negative bacterium Escherichia coli has been utilized to demonstrate the enhanced antibacterial activity of Ag-C-mannosyl nanoparticles towards this bacterium as compared to Ag-C-glycosyl nanoparticles.

Graphical abstract: Synthesis of Ag-glyconanoparticles using C-glycosides, their lectin binding studies and antibacterial activity

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Publication details

The article was received on 10 May 2013, accepted on 13 Aug 2013 and first published on 14 Aug 2013


Article type: Paper
DOI: 10.1039/C3NJ00496A
Citation: New J. Chem., 2013,37, 3716-3720

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    Synthesis of Ag-glyconanoparticles using C-glycosides, their lectin binding studies and antibacterial activity

    V. Ramtenki, D. Raju, U. J. Mehta, C. V. Ramana and B. L. V. Prasad, New J. Chem., 2013, 37, 3716
    DOI: 10.1039/C3NJ00496A

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