Issue 9, 2012
From the journal:

New Journal of Chemistry

Calcium doped mesoporous silicananoparticles as efficient alendronate delivery vehicles†

Jinlou Gu,*a   Meng Huang,a   Jiapeng Liu,a   Yongsheng Li,a   Wenru Zhaoa  and  Jianlin Shi*ab  

* Corresponding authors

a Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China
E-mail: jinlougu@ecust.edu.cn
Fax: +86-21-64252599
Tel: +86-21-64252599

b State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China

Abstract

Calcium doped mesoporous silica nanoparticles were successfully prepared and employed as efficient drug carriers for alendronate delivery. The incorporation of calcium ions dramatically enhanced the drug loading capacity and sustained release rate. The loaded alendronate more efficiently inhibited the growth of HeLa cancer cells than free drug.

Graphical abstract: Calcium doped mesoporous silica nanoparticles as efficient alendronate delivery vehicles

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2NJ40482F
Article type
Letter
Submitted
18 Apr 2012
Accepted
04 Jul 2012
First published
09 Jul 2012

New J. Chem., 2012,36, 1717-1720

Permissions

Request permissions

Calcium doped mesoporous silica nanoparticles as efficient alendronate delivery vehicles

J. Gu, M. Huang, J. Liu, Y. Li, W. Zhao and J. Shi, New J. Chem., 2012, 36, 1717 DOI: 10.1039/C2NJ40482F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements