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Issue 2, 2012
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Exponential diagnostic signal amplification via dendritic chain reaction: the dendritic effect of a self-immolative amplifier component

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Abstract

Signal amplification techniques are commonly used to boost diagnostic signals. We have recently developed a new approach for exponential signal amplification obtained through a distinctive dendritic chain reaction. Here we report evaluation of the effect of the self-immolative dendritic amplifier component on the signal amplification. Four dendrons with various numbers of end-units were evaluated for the ability to produce exponential signal amplification through self-immolative disassembly pathways. The dendron composed of a first-generation platform with three end-units exhibited the best characteristics with rapid disassembly rate and good stability under aqueous conditions. This study demonstrates the efficiency of molecules based on dendritic structures.

Graphical abstract: Exponential diagnostic signal amplification via dendritic chain reaction: the dendritic effect of a self-immolative amplifier component

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Publication details

The article was received on 06 Jun 2011, accepted on 27 Aug 2011 and first published on 23 Sep 2011


Article type: Paper
DOI: 10.1039/C1NJ20486F
Citation: New J. Chem., 2012,36, 386-393

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    Exponential diagnostic signal amplification via dendritic chain reaction: the dendritic effect of a self-immolative amplifier component

    N. Karton-Lifshin and D. Shabat, New J. Chem., 2012, 36, 386
    DOI: 10.1039/C1NJ20486F

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