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Issue 2, 2012
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Dendrimer therapeutics: covalent and ionic attachments

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Abstract

This concise review focuses on dendrimers functionalized by different linkers required for covalent and ionic attachments of drugs to the dendrimer's surface and highlights the importance of the chemical nature of linkers for controlled release of free drugs. The stability of linkers under physiological conditions and their lability under acidic conditions such as those of endosomes and lysosomes or under enzymatic conditions will be discussed. Especially, we review functionality of the most recently reported drug–dendrimer conjugates. Then, we give a short comparison of dendrimer conjugates versus either dendrimer complexes or polymer therapeutics and finally we briefly summarize the importance of both targeted and nontargeted covalently conjugated drugs.

Graphical abstract: Dendrimer therapeutics: covalent and ionic attachments

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Publication details

The article was received on 31 May 2011, accepted on 18 Aug 2011 and first published on 08 Sep 2011


Article type: Perspective
DOI: 10.1039/C1NJ20459A
Citation: New J. Chem., 2012,36, 227-240

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    Dendrimer therapeutics: covalent and ionic attachments

    S. El Kazzouli, S. Mignani, M. Bousmina and J. Majoral, New J. Chem., 2012, 36, 227
    DOI: 10.1039/C1NJ20459A

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