Syntheses of a series of S6 thioether cages and their coordination chemistry with Ag+

Roger Alberto; Daniela Angst; Kirstin Ortner; Ulrich Abram; P. August Schubiger; Thomas A. Kaden

doi:10.1039/B606510B

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Syntheses of a series of S₆ thioether cages and their coordination chemistry with Ag⁺†

Roger Alberto,^a Daniela Angst,^bc Kirstin Ortner,^a Ulrich Abram,^d P. August Schubiger^c and Thomas A. Kaden*^b

Author affiliations

* Corresponding authors

^a Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, Zürich, Switzerland
E-mail: ariel@aci.unizh.ch
Fax: +41 1 635 6803

^b Department of Chemistry, University of Basel, Spitalstrasse 51, Basel, Switzerland
E-mail: th.kaden@unibas.ch
Fax: +41 61 267 10 20

^c Center for Radiopharmaceutical Science, Paul Scherrer Institute, Villigen PSI, Switzerland

^d Institute of Chemistry, Freie Universität Berlin, Fabeckstrasse 34-36, Berlin, Germany

Abstract

The syntheses of four S₆-cages with different cavity sizes are described. In regard of potential applications for radioimmunotherapy with ¹¹¹Ag, their coordination behaviour towards Ag(I) was evaluated by studies of their reactivity in solution and of their crystal structures. All cages reacted differently with Ag(I). Whereas S₆-cages based on 3,8,12,17,20,25-hexathiabicyclo[8.8.8]-hexacosane (14) and on 5,9,17,21,28,31-hexathiabicyclo[11.11.11]pentatriacontane (18) showed only external Ag(I) coordination, successive adaptation of the cage size, yielded ligand 24, based on 4,7,13,21,24,25-hexathiabicyclo[8.8.8]hexacosane, which gave a complex with internal-peripheral Ag(I) binding.

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Article information

DOI: https://doi.org/10.1039/B606510B
Article type: Paper
Submitted: 08 May 2006
Accepted: 12 Jan 2007
First published: 02 Feb 2007

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New J. Chem., 2007,31, 409-417

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Syntheses of a series of S₆ thioether cages and their coordination chemistry with Ag⁺

R. Alberto, D. Angst, K. Ortner, U. Abram, P. A. Schubiger and T. A. Kaden, New J. Chem., 2007, 31, 409 DOI: 10.1039/B606510B

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