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Issue 12, 2006
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Computer-guided design of a Cu(ii) receptor and sensor

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Abstract

The computer program CAVEAT was used to design a linker structure to connect four imidazole 4-carboxamide groups in a distorted square planar arrangement optimal for binding Cu(II) ions. The resulting macrocyclic structure was prepared by the synthesis of a protected monomer followed by amide coupling reactions to form the cyclic tetramer. Binding to Cu(II) ion was evaluated using the inherent fluorescence of the receptor and its quenching upon binding to Cu(II) ion. Much higher concentrations of Zn(II), Co(II), and Ni(II) ions had little or no effect on the fluorescence and did not significantly compete with the fluorescence response to Cu(II) ions.

Graphical abstract: Computer-guided design of a Cu(ii) receptor and sensor

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Article information


Submitted
01 Aug 2006
Accepted
21 Aug 2006
First published
14 Sep 2006

New J. Chem., 2006,30, 1725-1730
Article type
Paper

Computer-guided design of a Cu(II) receptor and sensor

C. Lin and D. G. Drueckhammer, New J. Chem., 2006, 30, 1725 DOI: 10.1039/B610887C

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