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Issue 6, 2001
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The aluminium(III) complex of hypocrellin B as a PDT photosensitizer

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Abstract

The complex of hypocrellin B (HB) with aluminium was synthesized to improve the water solubility and red absorption of the parent pigment. The complexation of HB with Al3+ resulted in the formation of a complex with 1 : 1 Al(III) : HB stoichiometry (Al3+–HB) measured by molar ratio and continuous variation methods, respectively. The structure of this complex has been characterized by UV-Vis, IR, 1H NMR and elemental analysis data. Compared with HB, the complex possesses excellent solubility in water; in addition, the absorption wavelength of Al3+–HB shifts bathochromically into the phototherapeutic window (600–900 nm). The generation of active oxygen species, including the superoxide radical anion (O2•−) and singlet oxygen (1O2), by Al3+–HB photosensitization was observed. The efficiency of O2•− generation by Al3+–HB was twice as much as that of HB. Under our experimental conditions, the rate of O2•− generation by Al3+–HB was about 2.3 μM min−1 measured by the cytochrome c reduction method using 578 nm light. The quantum yield of singlet oxygen (1O2) was 0.23 in DMSO determined by the 9,10-DPA (diphenylanthracene) photobleaching experiments. These results suggest that the new complex possesses an enhanced type I process but a decreased type II process as compared with hypocrellin B.

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Article information


Submitted
02 Mar 2001
Accepted
02 Apr 2001
First published
16 May 2001

New J. Chem., 2001,25, 847-852
Article type
Paper

The aluminium(III) complex of hypocrellin B as a PDT photosensitizer

J. Ma, J. Zhao and L. Jiang, New J. Chem., 2001, 25, 847
DOI: 10.1039/B102011K

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