Issue 8, 2021

Kinetics of nanoparticle uptake into and distribution in human cells

Abstract

Whether one wishes to optimise drug delivery using nano-sized carriers or avoid hazard posed by engineered nanomaterials, the kinetics of nanoparticle uptake into human cells and their subsequent intracellular distribution is key. Unique properties of the nanoscale implies that such nanoparticles are taken up and trafficked in a different fashion compared to molecular species. In this review, we discuss in detail how to describe the kinetics of nanoparticle uptake and intracellular distribution, using previous studies for illustration. We also cover the extracellular kinetics, particle degradation, endosomal escape and cell division, ending with an outlook on the future of kinetic studies.

Graphical abstract: Kinetics of nanoparticle uptake into and distribution in human cells

Article information

Article type
Review Article
Submitted
27 Aug 2020
Accepted
12 Mar 2021
First published
18 Mar 2021
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2021,3, 2196-2212

Kinetics of nanoparticle uptake into and distribution in human cells

C. Åberg, Nanoscale Adv., 2021, 3, 2196 DOI: 10.1039/D0NA00716A

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