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Issue 9, 2020

Nanoscale laser-induced breakdown spectroscopy imaging reveals chemical distribution with subcellular resolution

Author affiliations

Abstract

Understanding chemical compositions is one of the most important parts in exploring the microscopic world. As a simple method for elemental detection, laser-induced breakdown spectroscopy (LIBS) is widely used in materials, geological and life science fields. However, due to the long-existing limitation in spatial resolution, it is difficult for LIBS to play an analytical role in the field of micro-world. Herein, we first report a reliable nanoscale resolution LIBS imaging technique by introducing a sampling laser with a micro-lensed fiber. Through the emission enhancement using the double-pulse laser, we obtained the spectral signal from a sampling crater of less than 500 nanometers in diameter, and visualized the chemical distribution of the self-made grid sample, SIM chip and nano-particles in single cells. The relative limits of detection (RLODs) of In and absolute limits of detection (ALODs) of Al can reach 0.6% and 18.3 fg, respectively.

Graphical abstract: Nanoscale laser-induced breakdown spectroscopy imaging reveals chemical distribution with subcellular resolution

Article information


Submitted
10 May 2020
Accepted
27 Jun 2020
First published
29 Jun 2020

This article is Open Access

Nanoscale Adv., 2020,2, 3983-3990
Article type
Paper

Nanoscale laser-induced breakdown spectroscopy imaging reveals chemical distribution with subcellular resolution

Y. Meng, C. Gao, Z. Lin, W. Hang and B. Huang, Nanoscale Adv., 2020, 2, 3983 DOI: 10.1039/D0NA00380H

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