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Issue 5, 2019
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Bio-inspired temporal regulation of ion-transport in nanochannels

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Abstract

Temporal regulation of mass transport across the membrane is a vital feature of biological systems. Such regulatory mechanisms rely on complex biochemical reaction networks, often operating far from equilibrium. Herein, we demonstrate biochemical reaction mediated temporal regulation of mass transport in nanochannels of mesoporous silica sphere. The rationally designed nanochannels with pH responsive electrostatic gating are fabricated through a hetero-functionalization approach utilizing propylamine and carboxylic acid moieties. At basic pH, cationic small molecules can diffuse into the nanochannels which release back to the solution at acidic pH. The transient ion transport is temporally controlled using a base as fuel along with esterase enzyme as the mediator. The slow enzymatic hydrolysis of a dormant deactivator (ethyl acetate) determines the lifetime of transient encapsulated state, which can be programmed easily by modulating the enzymatic activity of esterase. This system represents a unique approach to create autonomous artificial cellular models.

Graphical abstract: Bio-inspired temporal regulation of ion-transport in nanochannels

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Article information


Submitted
24 Dec 2018
Accepted
11 Mar 2019
First published
12 Mar 2019

This article is Open Access

Nanoscale Adv., 2019,1, 1847-1852
Article type
Paper

Bio-inspired temporal regulation of ion-transport in nanochannels

K. P. Sonu, S. Vinikumar, S. Dhiman, S. J. George and M. Eswaramoorthy, Nanoscale Adv., 2019, 1, 1847 DOI: 10.1039/C8NA00414E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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