Arsenic trioxide preferentially binds to the ring finger protein PML: understanding target selection of the drug

Cao Kaiming; Yaping Sheng; Shihui Zheng; Siming Yuan; Guangming Huang; Yangzhong Liu

doi:10.1039/C8MT00202A

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Arsenic trioxide preferentially binds to the ring finger protein PML: understanding target selection of the drug†

Cao Kaiming,^a Yaping Sheng,^a Shihui Zheng,^a Siming Yuan,^a Guangming Huang

^a and Yangzhong Liu

*^a

Author affiliations

* Corresponding authors

^a CAS Key Laboratory of Soft Matter Chemistry, CAS High Magnetic Field Laboratory, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China
E-mail: liuyz@ustc.edu.cn

Abstract

Arsenic trioxide (ATO) is used in the clinic for the treatment of acute promyelocytic leukemia by targeting the protein PML. However, many zinc-finger proteins could also be reactive to arsenic in cells. Here we found that ATO preferentially binds to the ring-finger domain of PML in a protein mixture with zinc-finger domains. These results provide the molecular basis of the target selection of ATO in cells.