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Issue 2, 2017
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Iron and inflammation – the gut reaction

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Abstract

Anemia is a frequent complication of many inflammatory disorders, including inflammatory bowel disease. Although the pathogenesis of this problem is multifactorial, a key component is the abnormal elevation of the hormone hepcidin, the central regulator of systemic iron homeostasis. Investigations over the last decade have resulted in important insights into the role of hepcidin in iron metabolism and the mechanisms that lead to hepcidin dysregulation in the context of inflammation. These insights provide the foundation for novel strategies to prevent and treat the anemia associated with inflammatory diseases.

Graphical abstract: Iron and inflammation – the gut reaction

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Article information


Submitted
29 Nov 2016
Accepted
03 Jan 2017
First published
03 Jan 2017

Metallomics, 2017,9, 101-111
Article type
Critical Review

Iron and inflammation – the gut reaction

S. Verma and B. J. Cherayil, Metallomics, 2017, 9, 101
DOI: 10.1039/C6MT00282J

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