Jump to main content
Jump to site search

Issue 2, 2016
Previous Article Next Article

The contribution of zinc to platelet behaviour during haemostasis and thrombosis

Author affiliations

Abstract

Platelets are the primary cellular determinants of haemostasis and pathological thrombus formation leading to myocardial infarction and stroke. Following vascular injury or atherosclerotic plaque rupture, platelets are recruited to sites of damage and undergo activation induced by a variety of soluble and/or insoluble agonists. Platelet activation is a multi-step process culminating in the formation of thrombi, which contribute to the haemostatic process. Zinc (Zn2+) is acknowledged as an important signalling molecule in a diverse range of cellular systems, however there is limited understanding of the influence of Zn2+ on platelet behaviour during thrombus formation. This review evaluates the contributions of exogenous and intracellular Zn2+ to platelet function and assesses the potential pathophysiological implications of Zn2+ signalling. We also provide a speculative assessment of the mechanisms by which platelets could respond to changes in extracellular and intracellular Zn2+ concentration.

Graphical abstract: The contribution of zinc to platelet behaviour during haemostasis and thrombosis

Back to tab navigation

Publication details

The article was received on 25 Sep 2015, accepted on 15 Dec 2015 and first published on 15 Dec 2015


Article type: Critical Review
DOI: 10.1039/C5MT00251F
Metallomics, 2016,8, 144-155

  •   Request permissions

    The contribution of zinc to platelet behaviour during haemostasis and thrombosis

    K. A. Taylor and N. Pugh, Metallomics, 2016, 8, 144
    DOI: 10.1039/C5MT00251F

Search articles by author

Spotlight

Advertisements