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Issue 6, 2015
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An evolutionary perspective on zinc uptake by human fungal pathogens

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Abstract

The mammalian immune system has evolved sophisticated mechanisms to withhold essential micronutrients from invading pathogens. These processes, collectively known as nutritional immunity serve to limit microbial proliferation and bolster killing of the invader. Successful pathogens, therefore, have developed strategies to counteract nutritional immunity and acquire essential micronutrients in the restrictive environment of the infected host. Here I take advantage of the now large number of sequenced fungal genomes to explore the zinc acquisition strategies of human fungal pathogens and reflect on the evolutionary context of these uptake pathways.

Graphical abstract: An evolutionary perspective on zinc uptake by human fungal pathogens

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Publication details

The article was received on 15 Dec 2014, accepted on 26 Jan 2015 and first published on 26 Jan 2015


Article type: Perspective
DOI: 10.1039/C4MT00331D
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Citation: Metallomics, 2015,7, 979-985
  • Open access: Creative Commons BY license
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    An evolutionary perspective on zinc uptake by human fungal pathogens

    D. Wilson, Metallomics, 2015, 7, 979
    DOI: 10.1039/C4MT00331D

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