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Issue 8, 2014
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Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery

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Abstract

The unique properties of transition metal complexes, such as environment-responsive ligand exchange kinetics, diverse photochemical and photophysical properties, and the ability to form specific interactions with biomolecules, make them interesting platforms for selective drug delivery. This minireview will focus on recent examples of rationally designed complexes with bioactive ligands, exploring the different roles of the metal, and mechanisms of ligand release. Developments in the techniques used to study the mechanisms of action of metal–drug complexes will also be discussed, including X-ray protein crystallography, fluorescence lifetime imaging, and X-ray absorption spectroscopy.

Graphical abstract: Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery

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Publication details

The article was received on 07 Mar 2014, accepted on 14 May 2014 and first published on 14 May 2014


Article type: Minireview
DOI: 10.1039/C4MT00069B
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Metallomics, 2014,6, 1324-1335
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    Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery

    A. K. Renfrew, Metallomics, 2014, 6, 1324
    DOI: 10.1039/C4MT00069B

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