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Issue 10, 2014
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Metals and (metallo)proteins identification in vitreous humor focusing on post-mortem biochemistry

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Abstract

This work describes the evaluation of metals and (metallo)proteins in vitreous humor samples and their correlations with some biological aspects in different post-mortem intervals (1–7 days), taking into account both decomposing and non-decomposing bodies. After qualitative evaluation of the samples involving 26 elements, representative metal ions (Fe, Mg and Mo) are determined by inductively coupled plasma mass spectrometry after using mini-vial decomposition system for sample preparation. A significant trend for Fe is found with post-mortem time for decomposing bodies because of a significant increase of iron concentration when comparing samples from bodies presenting 3 and 7 days post-mortem interval. An important clue to elucidate the role of metals is the coupling of liquid chromatography with inductively coupled plasma mass spectrometry for identification of metals linked to proteins, as well as mass spectrometry for the identification of those proteins involved in the post-mortem interval.

Graphical abstract: Metals and (metallo)proteins identification in vitreous humor focusing on post-mortem biochemistry

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Publication details

The article was received on 18 Dec 2013, accepted on 27 Jun 2014 and first published on 30 Jun 2014


Article type: Paper
DOI: 10.1039/C3MT00373F
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Metallomics, 2014,6, 1801-1807

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    Metals and (metallo)proteins identification in vitreous humor focusing on post-mortem biochemistry

    J. C. Santos Júnior, P. C. Mollo Filho, R. B. Felice Guidugli, M. N. Eberlin, G. D. S. Pessôa, E. G. da Silva, M. A. Z. Arruda and N. F. Höehr, Metallomics, 2014, 6, 1801
    DOI: 10.1039/C3MT00373F

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