Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

There will be scheduled maintenance work beginning on Saturday 15th June 2019 at 8:30 am through to Sunday 16th June 2019 at 11:30 pm (BST).

During this time our website may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 8, 2012
Previous Article Next Article

Mammalian metallothioneins: properties and functions

Author affiliations

Abstract

Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their affinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective effects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc(II) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a possible negative role in resistance to heavy metal-based and non-heavy metal-based drugs.

Graphical abstract: Mammalian metallothioneins: properties and functions

Back to tab navigation

Publication details

The article was received on 07 Jan 2012, accepted on 13 Jun 2012 and first published on 13 Jun 2012


Article type: Critical Review
DOI: 10.1039/C2MT20081C
Metallomics, 2012,4, 739-750

  •   Request permissions

    Mammalian metallothioneins: properties and functions

    P. Babula, M. Masarik, V. Adam, T. Eckschlager, M. Stiborova, L. Trnkova, H. Skutkova, I. Provaznik, J. Hubalek and R. Kizek, Metallomics, 2012, 4, 739
    DOI: 10.1039/C2MT20081C

Search articles by author

Spotlight

Advertisements