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Issue 8, 2012
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Mammalian metallothioneins: properties and functions

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Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their affinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective effects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc(II) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a possible negative role in resistance to heavy metal-based and non-heavy metal-based drugs.

Graphical abstract: Mammalian metallothioneins: properties and functions

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Publication details

The article was received on 07 Jan 2012, accepted on 13 Jun 2012 and first published on 13 Jun 2012

Article type: Critical Review
DOI: 10.1039/C2MT20081C
Metallomics, 2012,4, 739-750

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    Mammalian metallothioneins: properties and functions

    P. Babula, M. Masarik, V. Adam, T. Eckschlager, M. Stiborova, L. Trnkova, H. Skutkova, I. Provaznik, J. Hubalek and R. Kizek, Metallomics, 2012, 4, 739
    DOI: 10.1039/C2MT20081C

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