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Issue 7, 2012
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Using metalloproteomics to investigate the cellular physiology of copper in hepatocytes

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Abstract

Proteomics is a systems biology approach for examining proteins and their function in a given specified system. Metalloproteomics narrows the focus of proteomics to those proteins which bind a metal or are metalloproteins. An important system where metalloproteomics can be applied is the hepatocyte, the liver's parenchymal cell engaged in protein synthesis, nutrient deployment, and drug biotransformation. Hepatocellular metalloproteomics is an exciting new scientific discipline which has already advanced our understanding of certain genetic and neoplastic liver disorders. It has the potential to elucidate the action of numerous metals in hepatocytes and generate new diagnostic parameters, namely, novel biomarkers.

Graphical abstract: Using metalloproteomics to investigate the cellular physiology of copper in hepatocytes

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Publication details

The article was received on 01 Feb 2012, accepted on 12 Apr 2012 and first published on 23 May 2012


Article type: Perspective
DOI: 10.1039/C2MT20019H
Metallomics, 2012,4, 633-640

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    Using metalloproteomics to investigate the cellular physiology of copper in hepatocytes

    E. A. Roberts, Metallomics, 2012, 4, 633
    DOI: 10.1039/C2MT20019H

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