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Issue 1, 2019
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Degradable silver-based nanoplatform for synergistic cancer starving-like/metal ion therapy

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Abstract

Developing a simple and degradable synergistic therapy nanosystem based on glucose oxidase (GOx) remains a challenge. Inspired by the chain reactions among silver nanoparticles, GOx and intratumoral glucose, a degradable GOx-conjugated silver nanocube (AgNC–GOx) for synergistic cancer starving-like/metal ion therapy is presented. The combination of glucose depletion, toxic H2O2 and Ag ions effectively inhibits tumor growth with minimal adverse effects.

Graphical abstract: Degradable silver-based nanoplatform for synergistic cancer starving-like/metal ion therapy

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Article information


Submitted
05 Aug 2018
Accepted
11 Oct 2018
First published
23 Oct 2018

Mater. Horiz., 2019,6, 169-175
Article type
Communication

Degradable silver-based nanoplatform for synergistic cancer starving-like/metal ion therapy

Y. Zhang, Y. Yang, S. Jiang, F. Li, J. Lin, T. Wang and P. Huang, Mater. Horiz., 2019, 6, 169
DOI: 10.1039/C8MH00908B

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