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Issue 5, 2016
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Mechanochemical functionalization of disulfide linked hydrogels

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Abstract

Poly(ethylene glycol) hydrogels with disulfide linkages are functionalized through applied force. Compression or tension induces bond rupture at the relatively weak disulfide linkages, which will subsequently react through Michael-type addition with an acceptor molecule within the gel. We demonstrate the utility of this approach by patterning cell adhesion proteins through compression of a lithographically structured stamp, where cells predominately adhere to the compressed regions.

Graphical abstract: Mechanochemical functionalization of disulfide linked hydrogels

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Article information


Submitted
30 Mar 2016
Accepted
26 May 2016
First published
02 Jun 2016

Mater. Horiz., 2016,3, 447-451
Article type
Communication

Mechanochemical functionalization of disulfide linked hydrogels

J. Lee, M. N. Silberstein, A. A. Abdeen, S. Y. Kim and K. A. Kilian, Mater. Horiz., 2016, 3, 447
DOI: 10.1039/C6MH00091F

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